Mechanisms, functions and evolution of Wnt signaling pathways
Concept
1st Funding Period (9.12.2008 - 8.12.2011)
The projects address the analysis of β-catenin-dependent and β-catenin-independent Wnt functions in embryonic development, organogenesis and organ remodeling in several animal models including Hydra/Nematostella (TP1, TP2, TP5), Drosophila (TP3), Xenopus (TP4, TP5, TP6) and mouse (TP7). The focus of the Forschergruppe is the functional analysis of Wnt pathway components in the context of embryonic development and evolution. In contrast, we will address neither the crosstalk between the Wnt pathway and other signaling cascades nor the role of Wnt signaling in tumor formation and progression. Instead, structure-function and comparative studies of Wnt-signaling components, pathways and regulators between invertebrates and vertebrates, are the main focus in our research group.
Thomas Holstein |
Function of Wnt-signaling in Hydra regeneration |
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Suat Özbek |
Structure-function relationships and evolution of Wnt signaling molecules |
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Michael Boutros |
Characterization of novel Wnt pathway modifiers identified by genome-wide RNAi screening |
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Doris Wedlich |
Molecular control of cell migration during Xenopus gastrulation by different Wnt signaling pathways |
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Dietmar Gradl |
Lef/Tcf transcription factors: regulation of subtype specificity |
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Herbert Steinbeisser |
Modulation of β-catenin-independent Wnt-signaling by secreted frizzled related proteins (sFRPs) |
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Stefan Hardt |
The role of Wnt signaling for myocardial function and cardiac remodeling following pathologic injury |
2nd Funding Period (9.12.2011 - 9.12.2014)
