Mechanisms, functions and evolution of Wnt signaling pathways
Publications
2nd Funding Period (FOR 1036/2, 9.12.2011 - 9.12.2014)
TP04: Dietmar Gradl
- Holzer, T., Liffers, K., Rahm, K., Trageser, B., Ozbek, S., Gradl, D. (2012). Live imaging of active fluorophore labelled Wnt proteins. FEBS Lett. 586:1638-1644.
» Link to the publication
TP06: Herbert Steinbeisser
- Kietzmann, A., Wang, Y., Weber, D., Steinbeisser, H. (2012). Xenopus paraxial protocadherin inhibits Wnt/β-catenin signalling via casein kinase 2β. EMBO Rep. 13:129-34.
» Link to the publication
AP2: Matthias Carl
- Beretta, C.A., Dross, N., Gutierrez-Triana, J.A., Ryu, S., Carl, M. (2012). Habenula circuit development: past, present and future. Frontiers in Neuroscience 6:51.
» Link to the publication
1st Funding Period (FOR 1036, 9.12.2008 - 8.12.2011)
TP1: Thomas Holstein
- Nakamura, Y., Tsiairis, C.D., Özbek, S., Holstein, T.W. (2011). Autoregulatory and repressive inputs localize Hydra Wnt3 to the head organizer. Proc. Natl. Acad. Sci. USA 108:9137-42.
» Link to the publication - Chapman, J., Kirkness, E.F., Simakov, O., Hampson, S.E., Mitros, T., Weinmaier, T., Rattei, T., Borman, J., Busam, D., Disbennett, K., Sumin, N., Sutton, G.G., Viswanathan, L.D., Walenz, B., Goodstein, D.M., Hellsten, U., Kawashima, T., Prochnik, S.E., Putnam, N.H., Shu, S., Blumberg, B., Dana, C.E., Gee, L., Kibler, D.F., Law, L., Lindgens, D., Martinez, D.E., Peng, J., Wigge, P.A., Balasubramanian, P., Bertulat, B., Guder, G., Nakamura, Y., Özbek, S., Watanabe, H., Kalthurin, K., Hemmrich, G., Franke, A., Augustin, R., Fraune, S., Hayakawa, E., Hayakawa, S., Hirose, M., Hwang, J.S., Ikeo, K., Nishimiya-Fujisawa, C., Ogura, A., Takahasi, T., Steinmetz, P.R.H., Aufschnaiter, R., Eder, M., Gorny, A., Salvenmoser, W., Heimberg, A.M., Wheeler, B.M., Peterson, K.J., Böttger, A., Tischler P., Wolf, A., Gojobori, T., Remington, K.A., Strausberg, R.L., Venter, J.C., Technau, U., Hobmayer, B., Bosch, T.C.G., Holstein, T.W., Fujisawa, T., Bode, H.R., David, C.N., Rokhsar, D.S., Steele, R. (2010). The dynamic genome of Hydra. Nature 464:592-6.
» Link to the publication
TP2: Suat Özbek
- Nakamura, Y., Tsiairis, C.D., Özbek, S., Holstein, T.W. (2011). Autoregulatory and repressive inputs localize Hydra Wnt3 to the head organizer. Proc. Natl. Acad. Sci. USA 108:9137-42.
» Link to the publication - Chapman, J., Kirkness, E.F., Simakov, O., Hampson, S.E., Mitros, T., Weinmaier, T., Rattei, T., Borman, J., Busam, D., Disbennett, K., Sumin, N., Sutton, G.G., Viswanathan, L.D., Walenz, B., Goodstein, D.M., Hellsten, U., Kawashima, T., Prochnik, S.E., Putnam, N.H., Shu, S., Blumberg, B., Dana, C.E., Gee, L., Kibler, D.F., Law, L., Lindgens, D., Martinez, D.E., Peng, J., Wigge, P.A., Balasubramanian, P., Bertulat, B., Guder, G., Nakamura, Y., Özbek, S., Watanabe, H., Kalthurin, K., Hemmrich, G., Franke, A., Augustin, R., Fraune, S., Hayakawa, E., Hayakawa, S., Hirose, M., Hwang, J.S., Ikeo, K., Nishimiya-Fujisawa, C., Ogura, A., Takahasi, T., Steinmetz, P.R.H., Aufschnaiter, R., Eder, M., Gorny, A., Salvenmoser, W., Heimberg, A.M., Wheeler, B.M., Peterson, K.J., Böttger, A., Tischler P., Wolf, A., Gojobori, T., Remington, K.A., Strausberg, R.L., Venter, J.C., Technau, U., Hobmayer, B., Bosch, T.C.G., Holstein, T.W., Fujisawa, T., Bode, H.R., David, C.N., Rokhsar, D.S., Steele, R. (2010). The dynamic genome of Hydra. Nature 464:592-6.
» Link to the publication
TP3: Michael Boutros
- Buechling, T., Boutros, M. (2011). Wnt signaling signaling at and above the receptor level. Current Topics in Developmental Biology 97:21-53. » Link to the publication
- Buechling, T., Chaudhary, V., Spirohn, K., Weiss, M., Boutros, M. (2011). p24 proteins are required for secretion of Wnt ligands. EMBO Reports 12:1265-72.
» Link to the publication - Glinka, A., Dolde, C., Kirsch, N., Huang, Y.L., Kazanskaya, O., Ingelfinger, D., Boutros, M., Cruciat, C.M., Niehrs, C. (2011). LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling. EMBO reports 12(10):1055-61.
» Link to the publication - Liang, J., Fu, Y., Cruciat, C.M., Jia, S., Wang, Y., Tong, Z., Tao, Q., Ingelfinger, D., Boutros, M., Meng, A., Niehrs, C., Wu, W. (2011). Transmembrane Protein 198 Promotes LRP6 Phosphorylation and Wnt Signaling Activation. Molecular and Cellular Biology 31(13):2577-90.
» Link to the publication - Niehrs, C., Boutros, M. (2010). Trafficking, acidification, and growth factor signaling. Science Signaling 3:pe26.
» Link to the publication - Buechling, T., Bartscherer, K., Ohkawara, B., Chaudhary, V., Spirohn, K., Niehrs, C., Boutros, M. (2010). Wnt/Frizzled signaling requires dPRR, the Drosophila homolog of the prorenin receptor. Current Biology 20:1263-8.
» Link to the publication - Cruciat, C.M., Ohkawara, B., Acebron, S.P., Karaulanov, E., Reinhard, C., Ingelfinger, D., Boutros, M., Niehrs, C. (2010). Requirement of prorenin receptor an vacuolar H+-ATPase-mediated acidification for Wnt signaling. Science 327:459-63.
» Link to the publication - Davidson, G., Shen, J., Huang, Y.L., Su, Y., Karaulanov, E., Bartscherer, K., Hassler, C., Stannek, P., Boutros, M., Niehrs, C. (2009). Cell cycle control of wnt receptor activation. Developmental Cell 17:788-99.
» Link to the publication
TP3: Christoph Niehrs
- Ohkawara, B., Glinka, A., Niehrs, C. (2011). Rspo3 binds syndecan 4 and induces Wnt/PCP signaling via clathrin-mediated endocytosis to promote morphogenesis. Developmental cell 20: 303-314.
» Link to the publication - Glinka, A., Dolde, C., Kirsch, N., Huang, Y.L., Kazanskaya, O., Ingelfinger, D., Boutros, M., Cruciat, C.M., Niehrs, C. (2011). LGR4 and LGR5 are R-spondin receptors mediating Wnt/β-catenin and Wnt/PCP signalling. EMBO reports 12(10):1055-61.
» Link to the publication - Liang, J., Fu, Y., Cruciat, C.M., Jia, S., Wang, Y., Tong, Z., Tao, Q., Ingelfinger, D., Boutros, M., Meng, A., Niehrs, C., Wu, W. (2011). Transmembrane Protein 198 Promotes LRP6 Phosphorylation and Wnt Signaling Activation. Molecular and Cellular Biology 31(13):2577-90.
» Link to the publication - Ohkawara, B., Niehrs, C. (2011). An ATF2-based luciferase reporter to monitor non-canonical Wnt signaling in Xenopus embryos. Developmental Dynamics 240:188-94.
» Link to the publication - Niehrs, C., Boutros, M. (2010). Trafficking, acidification, and growth factor signaling. Science Signaling 3:pe26.
» Link to the publication - Davidson, G., Niehrs, C. (2010). Emerging links between CDK cell cycle regulators and Wnt signaling. Trends in Cell Biology 20: 453-60.
» Link to the publication - Buechling, T., Bartscherer, K., Ohkawara, B., Chaudhary, V., Spirohn, K., Niehrs, C., Boutros, M. (2010). Wnt/Frizzled signaling requires dPRR, the Drosophila homolog of the prorenin receptor. Current Biology 20:1263-8.
» Link to the publication - Schulze, J., Seitz, S., Saito, H., Schneebauer, M., Marshall, R.P., Baranowsky, A., Busse, B., Schilling, A.F., Friedrich, F.W., Albers, J., Spiro, A.S., Zustin, J., Streichert, T., Ellwanger, K., Niehrs, C., Amling, M., Baron, R., Schinke, T. (2010). Negative regulation of bone formation by the transmembrane Wnt antagonist Kremen-2. PLoS One 5:e10309.
» Link to the publication - Niehrs, C. (2010). On growth and form: a Cartesian coordinate system of Wnt and BMP signaling specifies bilaterian body axes. Development 137:845-57. Review
» Link to the publication - Wang, Y., Fu, Y., Gao, L., Zhu, G., Liang, J., Gao, C., Huang, B., Fenger, U., Niehrs, C., Chen, Y.G., Wu, W. (2010.) Xenopus skip modulates Wnt/beta-catenin signaling and functions in neural crest induction. The Journal of Biological Chemistry 285:10890-901.
» Link to the publication - Cruciat, C.M., Ohkawara, B., Acebron, S.P., Karaulanov, E., Reinhard, C., Ingelfinger, D., Boutros, M., Niehrs, C. (2010). Requirement of prorenin receptor an vacuolar H+-ATPase-mediated acidification for Wnt signaling. Science 327:459-63.
» Link to the publication - Davidson, G., Shen, J., Huang, Y.L., Su, Y., Karaulanov, E., Bartscherer, K., Hassler, C., Stannek, P., Boutros, M., Niehrs, C. (2009). Cell cycle control of wnt receptor activation. Developmental Cell 17:788-99.
» Link to the publication
TP4: Doris Wedlich
- Jung, B., Köhler, A., Schambony, A., Wedlich, D. (2011). PAPC and the Wnt5a/Ror2 pathway control the invagination of the oticplacode in Xenopus. BMC Dev. Biol. 11:36.
» Link to the publication - Rigo-Watermeier, T., Kraft, B., Ritthaler, M., Wallkamm, V., Holstein, T.W., Wedlich, D. (2011). Functional conservation of Nematostella Wnts in canonical and noncanonical Wnt-signaling. Biology Open1:43-51.
» Link to the publication - Koenig, S.F., Brentle, S., Hamdi, K., Fichtner, D., Wedlich, D., Gradl, D. (2010). En2, Pax2/5 and Tcf-4 transcription factors cooperate in patterning the Xenopus brain. Dev Biol. 340(2):318-328.
» Link to the publication
TP5: Dietmar Gradl
- Koenig, S.F., Brentle, S., Hamdi, K., Fichtner, D., Wedlich, D., Gradl, D. (2010). En2, Pax2/5 and Tcf-4 transcription factors cooperate in patterning the Xenopus brain. Developmental Biology 340: 318-28.
» Link to the publication
TP6: Herbert Steinbeisser
- Köster, I., Jungwirth, M.S., Steinbeisser, H. (2010). xGit2 and xRhoGAP 11A regulate convergent extension and tissue separation in Xenopus gastrulation. Dev. Biol. 344(1):26-35.
» Link to the publication
TP7: Stefan Hardt
- Hagenmüller, M., Malekar, P., Fieger, C., Weiss, C.S., Buss, S.J., Wolf, D., Katus, H.A., Hardt, S.E. (2010). Depletion of mammalian target of rapamycin (mTOR) via siRNA mediated knockdown leads to stabilization of β-catenin and elicits distinct features of cardiomyocyte hypertrophy. FEBS Letters 584: 74-80.
» Link to the publication - Malekar, P., Hagenmüller, M., Anyanwu, A., Buss, S., Streit, M.R., Weiss, C.S., Wolf, D., Riffel, J., Bauer, A., Katus, H.A., Hardt, S. E. (2010). Wnt signaling is critical for maladaptive cardiac hypertrophy and accelerates myocardial remodelling. Hypertension 55:939-945.
» Link to the publication
